| Ecosysteem | Type | Status | Ref. |
|---|---|---|---|
| Cumberland River | River (basin) | native | 86798 |
| Nearctic | Zoogeographic realm | endemic | 5723 |
| New River | River (basin) | native | 86798 |
| Ohio River | River (basin) | introduced | 10294 |
| Santee River | River (basin) | native | 86798 |
| Savannah River | River (basin) | native | 86798 |
| St. Francis River | River (basin) | native | 86798 |
| Tennessee River | River (basin) | native | 5723 |
| White | River (basin) | native | 86798 |